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ΔF508-CFTR Modulator Screen Based on Cell Surface Targeting of a Chimeric Nucleotide Binding Domain 1 Reporter

The most common cystic fibrosis–causing mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) is deletion of phenylalanine at residue 508 (ΔF508). The ΔF508 mutation impairs folding of nucleotide binding domain 1 (NBD1) and interfacial interactions of NBD1 and the membrane spann...

詳細記述

保存先:
書誌詳細
出版年:SLAS Discov
主要な著者: Phuan, Puay-Wah, Veit, Guido, Tan, Joseph-Anthony, Roldan, Ariel, Finkbeiner, Walter E., Haggie, Peter M., Lukacs, Gergely L., Verkman, Alan S.
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6133293/
https://ncbi.nlm.nih.gov/pubmed/29533733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2472555218763310
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