Click-based synthesis of triazolobithiazole ΔF508-CFTR correctors for cystic fibrosis

Copper catalyzed azide-alkyne cycloaddition (CuAAC) chemistry is reported for the construction of previously unknown 5-(1H-1,2,3-triazol-1-yl)-4,5′-bithiazoles from 2-bromo-1-(thiazol-5-yl)ethanones. These novel triazolobithiazoles are shown to have cystic fibrosis (CF) corrector activity and, compa...

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Détails bibliographiques
Auteurs principaux: Donald, Michael B., Rodriguez, Kevin X., Shay, Hannah, Phuan, Puay-Wah, Verkman, A.S., Kurth, Mark J.
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419814/
https://ncbi.nlm.nih.gov/pubmed/22841006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.06.046
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