Click-based synthesis of triazolobithiazole ΔF508-CFTR correctors for cystic fibrosis

Copper catalyzed azide-alkyne cycloaddition (CuAAC) chemistry is reported for the construction of previously unknown 5-(1H-1,2,3-triazol-1-yl)-4,5′-bithiazoles from 2-bromo-1-(thiazol-5-yl)ethanones. These novel triazolobithiazoles are shown to have cystic fibrosis (CF) corrector activity and, compa...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Donald, Michael B., Rodriguez, Kevin X., Shay, Hannah, Phuan, Puay-Wah, Verkman, A.S., Kurth, Mark J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419814/
https://ncbi.nlm.nih.gov/pubmed/22841006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.06.046
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares