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Click-based synthesis of triazolobithiazole ΔF508-CFTR correctors for cystic fibrosis
Copper catalyzed azide-alkyne cycloaddition (CuAAC) chemistry is reported for the construction of previously unknown 5-(1H-1,2,3-triazol-1-yl)-4,5′-bithiazoles from 2-bromo-1-(thiazol-5-yl)ethanones. These novel triazolobithiazoles are shown to have cystic fibrosis (CF) corrector activity and, compa...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3419814/ https://ncbi.nlm.nih.gov/pubmed/22841006 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.06.046 |
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