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Isoxazolopyrimidines as Novel ΔF508-CFTR Correctors
Using a cell-based high-throughput screen, we identified isoxazolo[5,4-d]pyrimidines as novel small-molecule correctors of the cystic fibrosis mutant protein ΔF508-CFTR. 22 Isoxazolo[5,4-d]pyrimidine analogues were synthesized and tested. Synthesis of the key intermediate, 5-amino-3-arylisoxazole-4-...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3662250/ https://ncbi.nlm.nih.gov/pubmed/23710112 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1055/s-0029-1219781 |
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