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Isoxazolopyrimidines as Novel ΔF508-CFTR Correctors

Using a cell-based high-throughput screen, we identified isoxazolo[5,4-d]pyrimidines as novel small-molecule correctors of the cystic fibrosis mutant protein ΔF508-CFTR. 22 Isoxazolo[5,4-d]pyrimidine analogues were synthesized and tested. Synthesis of the key intermediate, 5-amino-3-arylisoxazole-4-...

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Autori principali: Yu, Gui Jun, Yang, Baoxue, Verkman, A. S., Kurth, Mark J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3662250/
https://ncbi.nlm.nih.gov/pubmed/23710112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1055/s-0029-1219781
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