Functional Fluorescently Labeled Bithiazole ΔF508-CFTR Corrector Imaged in Whole Body Slices in Mice

We previously reported the identification and structure-activity analysis of bithiazole-based correctors of defective cellular processing of the cystic fibrosis-causing CFTR mutant, ΔF508-CFTR. Here, we report the synthesis and uptake of a functional, fluorescently labeled bithiazole corrector. Foll...

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Bibliographic Details
Main Authors: Davison, Holly R., Taylor, Stephanie, Drake, Chris, Phuan, Puay-Wah, Derichs, Nico, Yao, Chenjuan, Jones, Ella F., Sutcliffe, Julie, Verkman, A. S., Kurth, Mark J.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245868/
https://ncbi.nlm.nih.gov/pubmed/22034937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc2004457
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