Hydrolytic Reactivity Trends among Potential Prodrugs of the O(2)-Glycosylated Diazeniumdiolate Family. Targeting Nitric Oxide to Macrophages for Antileishmanial Activity

[Image: see text] Glycosylated diazeniumdiolates of structure R(2)NN(O)=NO−R′ (R′ = a saccharide residue) are potential prodrugs of the nitric oxide (NO)-releasing but acid-sensitive R(2)NN(O)=NO(−) ion. Moreover, cleaving the acid-stable glycosides under alkaline conditions provides a convenient pr...

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Detalhes bibliográficos
Main Authors: Valdez, Carlos A., Saavedra, Joseph E., Showalter, Brett M., Davies, Keith M., Wilde, Thomas C., Citro, Michael L., Barchi, Joseph J., Deschamps, Jeffrey R., Parrish, Damon, El-Gayar, Stefan, Schleicher, Ulrike, Bogdan, Christian, Keefer, Larry K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2008
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574667/
https://ncbi.nlm.nih.gov/pubmed/18533711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8000482
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