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Hydrolytic Reactivity Trends among Potential Prodrugs of the O(2)-Glycosylated Diazeniumdiolate Family. Targeting Nitric Oxide to Macrophages for Antileishmanial Activity
[Image: see text] Glycosylated diazeniumdiolates of structure R(2)NN(O)=NO−R′ (R′ = a saccharide residue) are potential prodrugs of the nitric oxide (NO)-releasing but acid-sensitive R(2)NN(O)=NO(−) ion. Moreover, cleaving the acid-stable glycosides under alkaline conditions provides a convenient pr...
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| Main Authors: | , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical Society
2008
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2574667/ https://ncbi.nlm.nih.gov/pubmed/18533711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8000482 |
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