Structural modifications modulate stability of glutathione-activated arylated diazeniumdiolate prodrugs

JS-K, a diazeniumdiolate-based nitric oxide (NO)-releasing prodrug, is currently in late pre-clinical development as an anti-cancer drug candidate. This prodrug was designed to be activated by glutathione (GSH) to release NO. To increase the potency of JS-K, we are investigating the effect of slowin...

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Detalhes bibliográficos
Main Authors: Nandurdikar, Rahul S., Maciag, Anna E., Holland, Ryan J., Cao, Zhao, Shami, Paul J., Anderson, Lucy M., Keefer, Larry K., Saavedra, Joseph E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3590845/
https://ncbi.nlm.nih.gov/pubmed/22480849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.02.045
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