Rationale for co-targeting IGF-1R and ALK in ALK fusion positive lung cancer

Por Lovly, Christine M., McDonald, Nerina T., Chen, Heidi, Ortiz-Cuaran, Sandra, Heukamp, Lukas C., Yan, Yingjun, Florin, Alexandra, Ozretić, Luka, Lim, Diana, Wang, Lu, Chen, Zhao, Chen, Xi, Lu, Pengcheng, Paik, Paul K., Shen, Ronglai, Jin, Hailing, Buettner, Reinhard, Ansén, Sascha, Perner, Sven, Brockmann, Michael, Bos, Marc, Wolf, Jürgen, Gardizi, Masyar, Wright, Gavin M., Solomon, Benjamin, Russell, Prudence A., Rogers, Toni-Maree, Suehara, Yoshiyuki, Red-Brewer, Monica, Tieu, Rudy, de Stanchina, Elisa, Wang, Qingguo, Zhao, Zhongming, Johnson, David H., Horn, Leora, Wong, Kwok-Kin, Thomas, Roman K., Ladanyi, Marc, Pao, William
Publicado em 2014

Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition

Por Tang, Yujie, Gholamin, Sharareh, Schubert, Simone, Willardson, Minde I., Lee, Alex, Bandopadhayay, Pratiti, Bergthold, Guillame, Masoud, Sabran, Nguyen, Brian, Vue, Nujsaubnusi, Balansay, Brianna, Yu, Furong, Oh, Sekyung, Woo, Pamelyn, Chen, Spenser, Ponnuswami, Anitha, Monje, Michelle, Atwood, Scott X., Whitson, Ramon J., Mitra, Siddhartha, Cheshier, Samuel H., Qi, Jun, Beroukhim, Rameen, Tang, Jean Y., Wechsler-Reya, Rob, Oro, Anthony E., Link, Brian A., Bradner, James E., Cho, Yoon-Jae
Publicado em 2014

An Intracellular Ca(2+) Channel is Required For Sarcolemma Repair to Prevent Muscular Dystrophy

Por Cheng, Xiping, Zhang, Xiaoli, Gao, Qiong, Samie, Mohammad Ali, Azar, Marlene, Tsang, Wai Lok, Dong, Libing, Sahoo, Nirakar, Li, Xinran, Zhuo, Yue, Garrity, Abigail G., Wang, Xiang, Ferrer, Marc, Dowling, James, Xu, Li, Han, Renzhi, Xu, Haoxing
Publicado em 2014

Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition

Por Xing, Luzhou, Dai, Zhenpeng, Jabbari, Ali, Cerise, Jane E, Higgins, Claire A, Gong, Weijuan, de Jong, Annemieke, Harel, Sivan, DeStefano, Gina M, Rothman, Lisa, Singh, Pallavi, Petukhova, Lynn, Mackay-Wiggan, Julian, Christiano, Angela M, Clynes, Raphael
Publicado no Nat Med (2014)

A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis

Por Dey, Bappaditya, Dey, Ruchi Jain, Cheung, Laurene S., Pokkali, Supriya, Guo, Haidan, Lee, Jong-Hee, Bishai, William R.
Publicado no Nat Med (2015)

An in vivo model of human small intestine using pluripotent stem cells

Por Watson, Carey L, Mahe, Maxime M, Múnera, Jorge, Howell, Jonathan C, Sundaram, Nambirajan, Poling, Holly M, Schweitzer, Jamie I, Vallance, Jefferson E, Mayhew, Christopher N, Sun, Ying, Grabowski, Gregory, Finkbeiner, Stacy R, Spence, Jason R, Shroyer, Noah F, Wells, James M, Helmrath, Michael A
Publicado no Nat Med (2014)

Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models

Por Schiffer, Mario, Teng, Beina, Gu, Changkyu, Shchedrina, Valentina A., Kasaikina, Marina, Pham, Vincent A., Hanke, Nils, Rong, Song, Gueler, Faikah, Schroder, Patricia, Tossidou, Irini, Park, Joon-Keun, Staggs, Lynne, Haller, Hermann, Erschow, Sergej, Hilfiker-Kleiner, Denise, Wei, Changli, Chen, Chuang, Tardi, Nicholas, Hakroush, Samy, Selig, Martin K., Vasilyev, Aleksandr, Merscher, Sandra, Reiser, Jochen, Sever, Sanja
Publicado no Nat Med (2015)

Dynamic regulation of cardiolipin by the lipid pump, ATP8b1, determines the severity of lung injury in experimental bacterial pneumonia

Por Ray, Nancy B., Durairaj, Lakshmi, Chen, Bill B., McVerry, Bryan J., Ryan, Alan J., Donahoe, Michael, Waltenbaugh, Alisa K., O’Donnell, Christopher P., Henderson, Florita C., Etscheidt, Christopher A., McCoy, Diann M., Agassandian, Marianna, Hayes-Rowan, Emily C., Coon, Tiffany A., Butler, Phillip L., Gakhar, Lokesh, Mathur, Satya N., Sieren, Jessica C., Tyurina, Yulia Y., Kagan, Valerian E., McLennan, Geoffrey, Mallampalli, Rama K.
Publicado no Nat Med (2010)

Abundance and unique repertoire of plasma cells secreting IgA autoantibodies to transglutaminase 2 in the intestinal lesion of celiac disease

Por Di Niro, Roberto, Mesin, Luka, Zheng, Nai-Ying, Stamnaes, Jorunn, Morrissey, Michael, Lee, Jane-Hwei, Huang, Min, Iversen, Rasmus, du Pré, M. Fleur, Qiao, Shuo-Wang, Lundin, Knut E. A., Wilson, Patrick C., Sollid, Ludvig M.
Publicado no Nat Med (2012)

Protection against Shiga-Toxigenic Escherichia coli by Non-Genetically Modified Organism Receptor Mimic Bacterial Ghosts

Por Paton, Adrienne W., Chen, Austen Y., Wang, Hui, McAllister, Lauren J., Höggerl, Florian, Mayr, Ulrike Beate, Shewell, Lucy K., Jennings, Michael P., Morona, Renato, Lubitz, Werner, Paton, James C.
Publicado no Infect Immun (2015)

Neuroprotective role of SIRT1 in mammalian models of Huntington’s disease through activation of multiple SIRT1 targets

Por Jiang, Mali, Wang, Jiawei, Fu, Jinrong, Du, Lin, Jeong, Hyun-Kyung, West, Tim, Xiang, Lan, Peng, Qi, Hou, Zhipeng, Cai, Huan, Seredenin, Tamara, Arbez, Nicolas, Zhu, Shanshan, Sommers, Katherine, Qian, Jennifer, Zhang, Jiangyang, Mori, Susumu, Yang, X. William, Tamashiro, Kellie L. K., Aja, Susan, Moran, Timothy H., Luthi-Carter, Ruth, Martin, Bronwen, Maudsley, Stuart, Mattson, Mark P., Cichewicz, Robert H., Ross, Christopher A., Holtzman, David M., Krainc, Dimitri, Duan, Wenzhen
Publicado no Nat Med (2011)

Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits pancreatic cancer progression

Por Alam, Muhammad S., Gaida, Matthias M., Bergmann, Frank, Lasitschka, Felix, Giese, Thomas, Giese, Nathalia A., Hackert, Thilo, Hinz, Ulf, Hussain, S. Perwez, Kozlov, Serguei V., Ashwell, Jonathan D.
Publicado no Nat Med (2015)

The Consensus Molecular Subtypes of Colorectal Cancer

Por Guinney, Justin, Dienstmann, Rodrigo, Wang, Xin, de Reyniès, Aurélien, Schlicker, Andreas, Soneson, Charlotte, Marisa, Laetitia, Roepman, Paul, Nyamundanda, Gift, Angelino, Paolo, Bot, Brian M., Morris, Jeffrey S., Simon, Iris M., Gerster, Sarah, Fessler, Evelyn, de Sousa e Melo, Felipe, Missiaglia, Edoardo, Ramay, Hena, Barras, David, Homicsko, Krisztian, Maru, Dipen, Manyam, Ganiraju C., Broom, Bradley, Boige, Valerie, Perez-Villamil, Beatriz, Laderas, Ted, Salazar, Ramon, Gray, Joe W., Hanahan, Douglas, Tabernero, Josep, Bernards, Rene, Friend, Stephen H., Laurent-Puig, Pierre, Medema, Jan Paul, Sadanandam, Anguraj, Wessels, Lodewyk, Delorenzi, Mauro, Kopetz, Scott, Vermeulen, Louis, Tejpar, Sabine
Publicado no Nat Med (2015)

Informatics framework of traditional Sino-Japanese medicine (Kampo) unveiled by factor analysis

Por Okada, Taketo, Afendi, Farit Mochamad, Yamazaki, Mami, Chida, Kaori Nakahashi, Suzuki, Makoto, Kawai, Rika, Kim, Miyuki, Namiki, Takao, Kanaya, Shigehiko, Saito, Kazuki
Publicado no J Nat Med (2015)

Autosomal-dominant immune dysregulation syndrome in humans with CTLA4 mutations

Por Schubert, Desirée, Bode, Claudia, Kenefeck, Rupert, Hou, Tie Zheng, Wing, James B., Kennedy, Alan, Bulashevska, Alla, Petersen, Britt-Sabina, Schäffer, Alejandro A., Grüning, Björn A., Unger, Susanne, Frede, Natalie, Baumann, Ulrich, Witte, Torsten, Schmidt, Reinhold E., Dueckers, Gregor, Niehues, Tim, Seneviratne, Suranjith, Kanariou, Maria, Speckmann, Carsten, Ehl, Stephan, Rensing-Ehl, Anne, Warnatz, Klaus, Rakhmanov, Mirzokhid, Thimme, Robert, Hasselblatt, Peter, Emmerich, Florian, Cathomen, Toni, Backofen, Rolf, Fisch, Paul, Seidl, Maximilian, May, Annette, Schmitt-Graeff, Annette, Ikemizu, Shinji, Salzer, Ulrich, Franke, Andre, Sakaguchi, Shimon, Walker, Lucy S.K., Sansom, David M., Grimbacher, Bodo
Publicado no Nat Med (2014)

Induction of human pancreatic beta cell replication by inhibitors of dual specificity tyrosine regulated kinase

Por Wang, Peng, Alvarez-Perez, Juan-Carlos, Felsenfeld, Dan P., Liu, Hongtao, Sivendran, Sharmila, Bender, Aaron, Kumar, Anil, Sanchez, Roberto, Scott, Donald K., Garcia-Ocaña, Adolfo, Stewart, Andrew F.
Publicado no Nat Med (2015)

CAUSEL: An epigenome and genome editing pipeline for establishing function of non-coding GWAS variants

Por Spisak, Sandor, Lawrenson, Kate, Fu, Yanfang, Csabai, Istvan, Cottman, Rebecca T., Haiman, Christopher, Han, Ying, Seo, Ji-Heui, Lenci, Romina, Li, Qiyuan, Tisza, Viktoria, Szallasi, Zoltan, Herbert, Zachery T., Chabot, Matthew, Pomerantz, Mark, Solymosi, Norbert, Gayther, Simon, Joung, J. Keith, Freedman, Matthew L.
Publicado no Nat Med (2015)

Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors

Por Du, Yi, Yamaguchi, Hirohito, Wei, Yongkun, Hsu, Jennifer L., Wang, Hung-Ling, Hsu, Yi-Hsin, Lin, Wan-Chi, Yu, Wen-Hsuan, Leonard, Paul G., Lee, Gilbert R., Chen, Mei-Kuang, Nakai, Katsuya, Hsu, Ming-Chuan, Chen, Chun-Te, Sun, Ye, Wu, Yun, Chang, Wei-Chao, Huang, Wen-Chien, Liu, Chien-Liang, Chang, Yuan-Ching, Chen, Chung-Hsuan, Park, Morag, Jones, Philip, Hortobagyi, Gabriel N., Hung, Mien-Chie
Publicado no Nat Med (2016)

CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma

Por Noll, Elisa M., Eisen, Christian, Stenzinger, Albrecht, Espinet, Elisa, Muckenhuber, Alexander, Klein, Corinna, Vogel, Vanessa, Klaus, Bernd, Nadler, Wiebke, Rösli, Christoph, Lutz, Christian, Kulke, Michael, Engelhardt, Jan, Zickgraf, Franziska M., Espinosa, Octavio, Schlesner, Matthias, Jiang, Xiaoqi, Kopp-Schneider, Annette, Neuhaus, Peter, Bahra, Marcus, Sinn, Bruno V., Eils, Roland, Giese, Nathalia A., Hackert, Thilo, Strobel, Oliver, Werner, Jens, Büchler, Markus W., Weichert, Wilko, Trumpp, Andreas, Sprick, Martin R.
Publicado no Nat Med (2016)

Long term Glycemic Control Using Polymer Encapsulated, Human Stem-Cell Derived β-cells in Immune Competent mice

Por Vegas, Arturo J., Veiseh, Omid, Gürtler, Mads, Millman, Jeffrey R., Pagliuca, Felicia W., Bader, Andrew R., Doloff, Joshua C., Li, Jie, Chen, Michael, Olejnik, Karsten, Tam, Hok Hei, Jhunjhunwala, Siddharth, Langan, Erin, Aresta-Dasilva, Stephanie, Gandham, Srujan, McGarrigle, James, Bochenek, Matthew A., Hollister-Lock, Jennifer, Oberholzer, Jose, Greiner, Dale L., Weir, Gordon C., Melton, Douglas A., Langer, Robert, Anderson, Daniel G.
Publicado no Nat Med (2016)