Abundance and unique repertoire of plasma cells secreting IgA autoantibodies to transglutaminase 2 in the intestinal lesion of celiac disease

Celiac disease (CD) is an immune mediated disorder in which mucosal autoantibodies to the enzyme transglutaminase 2 (TG2)(1) are generated in response to the exogenous antigen gluten(2) in individuals who are HLA-DQ2 or HLA-DQ8(3). We assessed in a comprehensive and non-biased manner the IgA anti-TG...

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Publicat a:Nat Med
Autors principals: Di Niro, Roberto, Mesin, Luka, Zheng, Nai-Ying, Stamnaes, Jorunn, Morrissey, Michael, Lee, Jane-Hwei, Huang, Min, Iversen, Rasmus, du Pré, M. Fleur, Qiao, Shuo-Wang, Lundin, Knut E. A., Wilson, Patrick C., Sollid, Ludvig M.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4533878/
https://ncbi.nlm.nih.gov/pubmed/22366952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2656
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