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Epitope-dependent Functional Effects of Celiac Disease Autoantibodies on Transglutaminase 2
Transglutaminase 2 (TG2) is a Ca(2+)-dependent cross-linking enzyme involved in the pathogenesis of CD. We have previously characterized a panel of anti-TG2 mAbs generated from gut plasma cells of celiac patients and identified four epitopes (epitopes 1–4) located in the N-terminal part of TG2. Bind...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5207253/ https://ncbi.nlm.nih.gov/pubmed/27784785 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.738161 |
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