Epitope-dependent Functional Effects of Celiac Disease Autoantibodies on Transglutaminase 2

Transglutaminase 2 (TG2) is a Ca(2+)-dependent cross-linking enzyme involved in the pathogenesis of CD. We have previously characterized a panel of anti-TG2 mAbs generated from gut plasma cells of celiac patients and identified four epitopes (epitopes 1–4) located in the N-terminal part of TG2. Bind...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Hnida, Kathrin, Stamnaes, Jorunn, du Pré, M. Fleur, Mysling, Simon, Jørgensen, Thomas J. D., Sollid, Ludvig M., Iversen, Rasmus
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2016
Ämnen:
Immunology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207253/
https://ncbi.nlm.nih.gov/pubmed/27784785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.738161
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