Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition

Hedgehog signaling drives oncogenesis in several cancers and strategies targeting this pathway have been developed, most notably through inhibition of Smoothened. However, resistance to Smoothened inhibitors occurs via genetic changes of Smoothened or other downstream Hedgehog components. Here, we o...

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主要な著者: Tang, Yujie, Gholamin, Sharareh, Schubert, Simone, Willardson, Minde I., Lee, Alex, Bandopadhayay, Pratiti, Bergthold, Guillame, Masoud, Sabran, Nguyen, Brian, Vue, Nujsaubnusi, Balansay, Brianna, Yu, Furong, Oh, Sekyung, Woo, Pamelyn, Chen, Spenser, Ponnuswami, Anitha, Monje, Michelle, Atwood, Scott X., Whitson, Ramon J., Mitra, Siddhartha, Cheshier, Samuel H., Qi, Jun, Beroukhim, Rameen, Tang, Jean Y., Wechsler-Reya, Rob, Oro, Anthony E., Link, Brian A., Bradner, James E., Cho, Yoon-Jae
フォーマット: Artigo
言語:Inglês
出版事項: 2014
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Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4108909/
https://ncbi.nlm.nih.gov/pubmed/24973920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3613
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