CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma

Although subtypes of pancreatic ductal adenocarcinoma (PDAC) were described, this malignancy is clinically still treated as a single disease. Here, we present patient-derived models representing the full spectrum of previously identified quasi-mesenchymal (QM-PDA), classical and exocrine-like PDAC s...

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Detaylı Bibliyografya
Yayımlandı:Nat Med
Asıl Yazarlar: Noll, Elisa M., Eisen, Christian, Stenzinger, Albrecht, Espinet, Elisa, Muckenhuber, Alexander, Klein, Corinna, Vogel, Vanessa, Klaus, Bernd, Nadler, Wiebke, Rösli, Christoph, Lutz, Christian, Kulke, Michael, Engelhardt, Jan, Zickgraf, Franziska M., Espinosa, Octavio, Schlesner, Matthias, Jiang, Xiaoqi, Kopp-Schneider, Annette, Neuhaus, Peter, Bahra, Marcus, Sinn, Bruno V., Eils, Roland, Giese, Nathalia A., Hackert, Thilo, Strobel, Oliver, Werner, Jens, Büchler, Markus W., Weichert, Wilko, Trumpp, Andreas, Sprick, Martin R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780258/
https://ncbi.nlm.nih.gov/pubmed/26855150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4038
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