Screening drug effects in patient‐derived cancer cells links organoid responses to genome alterations

Cancer drug screening in patient‐derived cells holds great promise for personalized oncology and drug discovery but lacks standardization. Whether cells are cultured as conventional monolayer or advanced, matrix‐dependent organoid cultures influences drug effects and thereby drug selection and clini...

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Detalhes bibliográficos
Publicado no:Mol Syst Biol
Main Authors: Jabs, Julia, Zickgraf, Franziska M, Park, Jeongbin, Wagner, Steve, Jiang, Xiaoqi, Jechow, Katharina, Kleinheinz, Kortine, Toprak, Umut H, Schneider, Marc A, Meister, Michael, Spaich, Saskia, Sütterlin, Marc, Schlesner, Matthias, Trumpp, Andreas, Sprick, Martin, Eils, Roland, Conrad, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5731348/
https://ncbi.nlm.nih.gov/pubmed/29180611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20177697
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