Modeling glioblastoma invasion using human brain organoids and single-cell transcriptomics

BACKGROUND: Glioblastoma (GBM) consists of devastating neoplasms with high invasive capacity, which have been difficult to study in vitro in a human-derived model system. Therapeutic progress is also limited by cellular heterogeneity within and between tumors, among other factors such as therapy res...

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Vydáno v:Neuro Oncol
Hlavní autoři: Krieger, Teresa G, Tirier, Stephan M, Park, Jeongbin, Jechow, Katharina, Eisemann, Tanja, Peterziel, Heike, Angel, Peter, Eils, Roland, Conrad, Christian
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Basic and Translational Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7594554/
https://ncbi.nlm.nih.gov/pubmed/32297954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa091
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