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Hypermutation takes the driver’s seat
Most pediatric tumors have only very few somatic mutations. However, a recent study revealed that a subset of tumors from children with congenital biallelic deficiency of DNA mismatch repair exhibits a mutational load surpassing almost all other cancers. In these ultra-hypermutated tumors, somatic m...
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| Опубликовано в: : | Genome Med |
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| Главные авторы: | , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BioMed Central
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4376156/ https://ncbi.nlm.nih.gov/pubmed/25821521 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-015-0159-x |
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