CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma

Although subtypes of pancreatic ductal adenocarcinoma (PDAC) were described, this malignancy is clinically still treated as a single disease. Here, we present patient-derived models representing the full spectrum of previously identified quasi-mesenchymal (QM-PDA), classical and exocrine-like PDAC s...

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Publicado no:Nat Med
Main Authors: Noll, Elisa M., Eisen, Christian, Stenzinger, Albrecht, Espinet, Elisa, Muckenhuber, Alexander, Klein, Corinna, Vogel, Vanessa, Klaus, Bernd, Nadler, Wiebke, Rösli, Christoph, Lutz, Christian, Kulke, Michael, Engelhardt, Jan, Zickgraf, Franziska M., Espinosa, Octavio, Schlesner, Matthias, Jiang, Xiaoqi, Kopp-Schneider, Annette, Neuhaus, Peter, Bahra, Marcus, Sinn, Bruno V., Eils, Roland, Giese, Nathalia A., Hackert, Thilo, Strobel, Oliver, Werner, Jens, Büchler, Markus W., Weichert, Wilko, Trumpp, Andreas, Sprick, Martin R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780258/
https://ncbi.nlm.nih.gov/pubmed/26855150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4038
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