Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models

Dysregulation of the actin cytoskeleton in podocytes represents a common pathway in the pathogenesis of proteinuria across a spectrum of chronic kidney diseases (CKD). The GTPase dynamin has been implicated in the maintenance of cellular architecture in podocytes through its direct interaction with...

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Foilsithe in:Nat Med
Main Authors: Schiffer, Mario, Teng, Beina, Gu, Changkyu, Shchedrina, Valentina A., Kasaikina, Marina, Pham, Vincent A., Hanke, Nils, Rong, Song, Gueler, Faikah, Schroder, Patricia, Tossidou, Irini, Park, Joon-Keun, Staggs, Lynne, Haller, Hermann, Erschow, Sergej, Hilfiker-Kleiner, Denise, Wei, Changli, Chen, Chuang, Tardi, Nicholas, Hakroush, Samy, Selig, Martin K., Vasilyev, Aleksandr, Merscher, Sandra, Reiser, Jochen, Sever, Sanja
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2015
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458177/
https://ncbi.nlm.nih.gov/pubmed/25962121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3843
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