Robust Cre-Mediated Recombination in Small Intestinal Stem Cells Utilizing the Olfm4 Locus

Por Schuijers, Jurian, van der Flier, Laurens G., van Es, Johan, Clevers, Hans
Publicado em 2014

Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia

Por Koo, Bon-Kyoung, van Es, Johan H., van den Born, Maaike, Clevers, Hans
Publicado no Proc Natl Acad Sci U S A (2015)

Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion

Por Snippert, Hugo J, Schepers, Arnout G, van Es, Johan H, Simons, Benjamin D, Clevers, Hans
Publicado em 2014

Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors

Por van Es, Johan H., de Geest, Natalie, van de Born, Maaike, Clevers, Hans, Hassan, Bassem A.
Publicado em 2010

Niche-independent high-purity cultures of Lgr5(+) intestinal stem cells and their progeny

Por Yin, Xiaolei, Farin, Henner F, van Es, Johan H, Clevers, Hans, Langer, Robert, Karp, Jeffrey M
Publicado em 2013

GRASP65 controls the cis Golgi integrity in vivo

Por Veenendaal, Tineke, Jarvela, Tim, Grieve, Adam G., van Es, Johan H., Linstedt, Adam D., Rabouille, Catherine
Publicado em 2014

Single molecule transcript counting of stem cell markers in the mouse intestine

Por Itzkovitz, Shalev, Lyubimova, Anna, Blat, Irene, Maynard, Mindy, van Es, Johan, Lees, Jacqueline, Jacks, Tyler, Clevers, Hans, van Oudenaarden, Alexander
Publicado em 2011

Retromer Dependent Recycling of the Wnt Secretion Factor Wls Is Dispensable for Stem Cell Maintenance in the Mammalian Intestinal Epithelium

Por de Groot, Reinoud E. A., Farin, Henner F., Macůrková, Marie, van Es, Johan H., Clevers, Hans C., Korswagen, Hendrik C.
Publicado em 2013

Mapping early fate determination in Lgr5(+) crypt stem cells using a novel Ki67-RFP allele

Por Basak, Onur, van de Born, Maaike, Korving, Jeroen, Beumer, Joep, van der Elst, Stefan, van Es, Johan H, Clevers, Hans
Publicado em 2014

Apc restoration promotes cellular differentiation and reestablishes crypt homeostasis in colorectal cancer

Por Dow, Lukas E, O’Rourke, Kevin P, Simon, Janelle, Tschaharganeh, Darjus F, van Es, Johan H, Clevers, Hans, Lowe, Scott W
Publicado no Cell (2015)

Inducible In Vivo Silencing of Brd4 Identifies Potential Toxicities of Sustained BET Protein Inhibition

Por Bolden, Jessica E., Tasdemir, Nilgun, Dow, Lukas E., van Es, Johan H., Wilkinson, John E., Zhao, Zhen, Clevers, Hans, Lowe, Scott W.
Publicado no Cell Rep (2014)

T-cell factor 4 (Tcf7l2) maintains proliferative compartments in zebrafish intestine

Por Muncan, Vanesa, Faro, Ana, Haramis, Anna-Pavlina G, Hurlstone, Adam F L, Wienholds, Erno, van Es, Johan, Korving, Jeroen, Begthel, Harry, Zivkovic, Danica, Clevers, Hans
Publicado em 2007

Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27(Kip1) and p57(Kip2)

Por Riccio, Orbicia, van Gijn, Marielle E, Bezdek, April C, Pellegrinet, Luca, van Es, Johan H, Zimber-Strobl, Ursula, Strobl, Lothar J, Honjo, Tasuku, Clevers, Hans, Radtke, Freddy
Publicado em 2008

Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research

Por Tetteh, Paul W., Kretzschmar, Kai, Begthel, Harry, van den Born, Maaike, Korving, Jeroen, Morsink, Folkert, Farin, Henner, van Es, Johan H., Offerhaus, G. Johan A., Clevers, Hans
Publicado no Proc Natl Acad Sci U S A (2016)

Investigation of Frizzled-5 during embryonic neural development in mouse

Por Burns, Carole J., Zhang, Jianmin, Brown, Erinn C., Van Bibber, Alyssa M., Van Es, Johan, Clevers, Hans, Ishikawa, Tomo-o, Taketo, M. Mark, Vetter, Monica L., Fuhrmann, Sabine
Publicado em 2008

Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium

Por Gerbe, François, van Es, Johan H., Makrini, Leila, Brulin, Bénédicte, Mellitzer, Georg, Robine, Sylvie, Romagnolo, Béatrice, Shroyer, Noah F., Bourgaux, Jean-François, Pignodel, Christine, Clevers, Hans, Jay, Philippe
Publicado em 2011

A Critical Role for the Wnt Effector Tcf4 in Adult Intestinal Homeostatic Self-Renewal

Por van Es, Johan H., Haegebarth, Andrea, Kujala, Pekka, Itzkovitz, Shalev, Koo, Bon-Kyoung, Boj, Sylvia F., Korving, Jeroen, van den Born, Maaike, van Oudenaarden, Alexander, Robine, Sylvie, Clevers, Hans
Publicado em 2012

Targeting development of incretin-producing cells increases insulin secretion

Por Petersen, Natalia, Reimann, Frank, van Es, Johan H., van den Berg, Bernard M., Kroone, Chantal, Pais, Ramona, Jansen, Erik, Clevers, Hans, Gribble, Fiona M., de Koning, Eelco J.P.
Publicado no J Clin Invest (2014)

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

Por Sato, Toshiro, van Es, Johan H., Snippert, Hugo J., Stange, Daniel E., Vries, Robert G., van den Born, Maaike, Barker, Nick, Shroyer, Noah F., van de Wetering, Marc, Clevers, Hans
Publicado em 2010

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

Por Huch, Meritxell, Dorrell, Craig, Boj, Sylvia F., van Es, Johan H., van de Wetering, Marc, Li, Vivian S.W., Hamer, Karien, Sasaki, Nobuo, Finegold, Milton J., Haft, Annelise, Grompe, Markus, Clevers, Hans
Publicado em 2013