Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research

Current mouse models for colorectal cancer often differ significantly from human colon cancer, being largely restricted to the small intestine. Here, we aim to develop a colon-specific inducible mouse model that can faithfully recapitulate human colon cancer initiation and progression. Carbonic anhy...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Tetteh, Paul W., Kretzschmar, Kai, Begthel, Harry, van den Born, Maaike, Korving, Jeroen, Morsink, Folkert, Farin, Henner, van Es, Johan H., Offerhaus, G. Johan A., Clevers, Hans
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2016
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081651/
https://ncbi.nlm.nih.gov/pubmed/27708166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614057113
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