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Adenomatous polyposis coli-deficient zebrafish are susceptible to digestive tract neoplasia
Truncation of the tumour suppressor adenomatous polyposis coli (APC) constitutively activates the Wnt/β-catenin signalling pathway. This event constitutes the primary transforming event in sporadic colorectal cancer in humans. Moreover, humans or mice carrying germline truncating mutations in APC de...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2006
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1456916/ https://ncbi.nlm.nih.gov/pubmed/16439994 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400638 |
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