Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids

High-grade serous ovarian cancer (HG-SOC)—often referred to as a “silent killer”—is the most lethal gynecological malignancy. The fallopian tube (murine oviduct) and ovarian surface epithelium (OSE) are considered the main candidate tissues of origin of this cancer. However, the relative contributio...

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Publicado en:Nat Commun
Main Authors: Lõhmussaar, Kadi, Kopper, Oded, Korving, Jeroen, Begthel, Harry, Vreuls, Celien P. H., van Es, Johan H., Clevers, Hans
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7253462/
https://ncbi.nlm.nih.gov/pubmed/32461556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16432-0
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