Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids

High-grade serous ovarian cancer (HG-SOC)—often referred to as a “silent killer”—is the most lethal gynecological malignancy. The fallopian tube (murine oviduct) and ovarian surface epithelium (OSE) are considered the main candidate tissues of origin of this cancer. However, the relative contributio...

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Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Lõhmussaar, Kadi, Kopper, Oded, Korving, Jeroen, Begthel, Harry, Vreuls, Celien P. H., van Es, Johan H., Clevers, Hans
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7253462/
https://ncbi.nlm.nih.gov/pubmed/32461556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16432-0
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