Stable expansion of high‐grade serous ovarian cancer organoids requires a low‐Wnt environment

High‐grade serous ovarian cancer (HGSOC) likely originates from the fallopian tube (FT) epithelium. Here, we established 15 organoid lines from HGSOC primary tumor deposits that closely match the mutational profile and phenotype of the parental tumor. We found that Wnt pathway activation leads to gr...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Hoffmann, Karen, Berger, Hilmar, Kulbe, Hagen, Thillainadarasan, Sukanija, Mollenkopf, Hans‐Joachim, Zemojtel, Tomasz, Taube, Eliane, Darb‐Esfahani, Silvia, Mangler, Mandy, Sehouli, Jalid, Chekerov, Radoslav, Braicu, Elena I, Meyer, Thomas F, Kessler, Mirjana
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7073464/
https://ncbi.nlm.nih.gov/pubmed/32009247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019104013
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