Chronic Chlamydia infection in human organoids increases stemness and promotes age-dependent CpG methylation

Chronic infections of the fallopian tubes with Chlamydia trachomatis (Ctr) cause scarring and can lead to infertility. Here we use human fallopian tube organoids and genital Ctr serovars D, K and E for long-term in vitro analysis. The epithelial monolayer responds with active expulsion of the bacter...

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Dades bibliogràfiques
Publicat a:Nat Commun
Autors principals: Kessler, Mirjana, Hoffmann, Karen, Fritsche, Kristin, Brinkmann, Volker, Mollenkopf, Hans-Joachim, Thieck, Oliver, Teixeira da Costa, Ana Rita, Braicu, Elena I., Sehouli, Jalid, Mangler, Mandy, Berger, Hilmar, Meyer, Thomas F.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6423033/
https://ncbi.nlm.nih.gov/pubmed/30886143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09144-7
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