Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27(Kip1) and p57(Kip2)

The crucial role of individual Notch receptors and the mechanism by which they maintain intestinal crypt progenitor cells were assessed by using a series of inducible gut-specific Notch mutant mice. We found that Notch1 and Notch2 receptors function redundantly in the gut, as only simultaneous loss...

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Main Authors: Riccio, Orbicia, van Gijn, Marielle E, Bezdek, April C, Pellegrinet, Luca, van Es, Johan H, Zimber-Strobl, Ursula, Strobl, Lothar J, Honjo, Tasuku, Clevers, Hans, Radtke, Freddy
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group 2008
נושאים:
Scientific Report
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2288761/
https://ncbi.nlm.nih.gov/pubmed/18274550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.7
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