Targeting development of incretin-producing cells increases insulin secretion

Glucagon-like peptide-1–based (GLP-1–based) therapies improve glycemic control in patients with type 2 diabetes. While these agents augment insulin secretion, they do not mimic the physiological meal-related rise and fall of GLP-1 concentrations. Here, we tested the hypothesis that increasing the nu...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Petersen, Natalia, Reimann, Frank, van Es, Johan H., van den Berg, Bernard M., Kroone, Chantal, Pais, Ramona, Jansen, Erik, Clevers, Hans, Gribble, Fiona M., de Koning, Eelco J.P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382243/
https://ncbi.nlm.nih.gov/pubmed/25500886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI75838
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