Acetaminophen-induced Liver Injury: from Animal Models to Humans

od Jaeschke, Hartmut, Xie, Yuchao, McGill, Mitchell R.
Wydane w J Clin Transl Hepatol (2014)

BENZYL ALCOHOL PROTECTS AGAINST ACETAMINOPHEN HEPATOTOXICITY BY INHIBITING CYTOCHROME P450 ENZYMES BUT CAUSES MITOCHONDRIAL DYSFUNCTION AND CELL DEATH AT HIGHER DOSES

od Du, Kuo, McGill, Mitchell R., Xie, Yuchao, Jaeschke, Hartmut
Wydane w Food Chem Toxicol (2015)

PATHOPHYSIOLOGICAL SIGNIFICANCE OF C-JUN N-TERMINAL KINASE IN ACETAMINOPHEN HEPATOTOXICITY

od Du, Kuo, Xie, Yuchao, McGill, Mitchell R., Jaeschke, Hartmut
Wydane w Expert Opin Drug Metab Toxicol (2015)

Acetaminophen-induced Liver Injury in Rats and Mice: Comparison of Protein Adducts, Mitochondrial Dysfunction, and Oxidative Stress in the Mechanism of Toxicity

od McGill, Mitchell R., Williams, C. David, Xie, Yuchao, Ramachandran, Anup, Jaeschke, Hartmut
Wydane 2012

Models of Drug-induced Liver Injury for Evaluation of Phytotherapeutics and Other Natural Products

od Jaeschke, Hartmut, Williams, C. David, McGill, Mitchell R., Xie, Yuchao, Ramachandran, Anup
Wydane 2013

RESVERATROL PREVENTS PROTEIN NITRATION AND RELEASE OF ENDONUCLEASES FROM MITOCHONDRIA DURING ACETAMINOPHEN HEPATOTOXICITY

od Du, Kuo, McGill, Mitchell R., Xie, Yuchao, Bajt, Mary Lynn, Jaeschke, Hartmut
Wydane w Food Chem Toxicol (2015)

Purinergic Receptor Antagonist A438079 Protects Against Acetaminophen-Induced Liver Injury by Inhibiting P450 Isoenzymes, Not by Inflammasome Activation

od Xie, Yuchao, Williams, C. David, McGill, Mitchell R., Lebofsky, Margitta, Ramachandran, Anup, Jaeschke, Hartmut
Wydane 2013

LITHOCHOLIC ACID FEEDING RESULTS IN DIRECT HEPATO-TOXICITY INDEPENDENT OF NEUTROPHIL FUNCTION IN MICE

od Woolbright, Benjamin L., Li, Feng, Xie, Yuchao, Farhood, Anwar, Fickert, Peter, Trauner, Michael, Jaeschke, Hartmut
Wydane 2014

Inhibitor of Apoptosis Signal-Regulating Kinase 1 Protects Against Acetaminophen-induced Liver Injury

od Xie, Yuchao, Ramachandran, Anup, Breckenridge, David G., Liles, John T., Lebofsky, Margitta, Farhood, Anwar, Jaeschke, Hartmut
Wydane w Toxicol Appl Pharmacol (2015)

Editor’s Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction

od Du, Kuo, Ramachandran, Anup, Weemhoff, James L., Chavan, Hemantkumar, Xie, Yuchao, Krishnamurthy, Partha, Jaeschke, Hartmut
Wydane w Toxicol Sci (2016)

The Receptor Interacting Protein Kinase 3 is a Critical Early Mediator of Acetaminophen-induced Hepatocyte Necrosis in Mice

od Ramachandran, Anup, McGill, Mitchell R., Xie, Yuchao, Ni, Hong-Min, Ding, Wen-Xing, Jaeschke, Hartmut
Wydane 2013

The role of the c-Jun N-terminal kinases 1/2 and receptor-interacting protein kinase 3 in furosemide-induced liver injury

od McGill, Mitchell R., Du, Kuo, Xie, Yuchao, Bajt, Mary Lynn, Ding, Wen-Xing, Jaeschke, Hartmut
Wydane w Xenobiotica (2014)

THE GAP JUNCTION INHIBITOR 2-AMINOETHOXY-DIPHENYL-BORATE PROTECTS AGAINST ACETAMINOPHEN HEPATOTOXICITY BY INHIBITING CYTOCHROME P450 ENZYMES AND C-JUN N-TERMINAL KINASE ACTIVATION

od Du, Kuo, Williams, C. David, McGill, Mitchell R., Xie, Yuchao, Farhood, Anwar, Vinken, Mathieu, Jaeschke, Hartmut
Wydane 2013

Mechanisms of Acetaminophen-induced Cell Death in Primary Human Hepatocytes

od Xie, Yuchao, McGill, Mitchell R., Dorko, Kenneth, Kumer, Sean C., Schmitt, Timothy M., Forster, Jameson, Jaeschke, Hartmut
Wydane 2014

Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes

od Xie, Yuchao, McGill, Mitchell R., Du, Kuo, Dorko, Kenneth, Kumer, Sean C., Schmitt, Timothy M., Ding, Wen-Xing, Jaeschke, Hartmut
Wydane w Toxicol Appl Pharmacol (2015)

Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen Hepatotoxicity

od Xie, Yuchao, Woolbright, Benjamin L., Kos, Milan, McGill, Mitchell R., Dorko, Kenneth, Kumer, Sean C., Schmitt, Timothy M., Jaeschke, Hartmut
Wydane w J Clin Transl Res (2015)

Removal of Acetaminophen-Protein Adducts by Autophagy Protects Against Acetaminophen-Induced Liver Injury in Mice

od Ni, Hong-Min, McGill, Mitchell R., Chao, Xiaojuan, Du, Kuo, Williams, Jessica A., Xie, Yuchao, Jaeschke, Hartmut, Ding, Wen-Xing
Wydane w J Hepatol (2016)

Lack of direct cytotoxicity of extracellular ATP against hepatocytes: role in the mechanism of acetaminophen hepatotoxicity

od Xie, Yuchao, Woolbright, Benjamin L., Kos, Milan, McGill, Mitchell R., Dorko, Kenneth, Kumer, Sean C., Schmitt, Timothy M., Jaeschke, Hartmut
Wydane w J Clin Transl Res (2015)

Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in Mice

od Bhushan, Bharat, Chavan, Hemantkumar, Borude, Prachi, Xie, Yuchao, Du, Kuo, McGill, Mitchell R, Lebofsky, Margitta, Jaeschke, Hartmut, Krishnamurthy, Partha, Apte, Udayan
Wydane w Toxicol Sci (2017)

Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells

od Xie, Yuchao, McGill, Mitchell R., Cook, Sarah F., Sharpe, Matthew R., Winefield, Robert D., Wilkins, Diana G., Rollins, Douglas E., Jaeschke, Hartmut
Wydane w Xenobiotica (2015)