THE GAP JUNCTION INHIBITOR 2-AMINOETHOXY-DIPHENYL-BORATE PROTECTS AGAINST ACETAMINOPHEN HEPATOTOXICITY BY INHIBITING CYTOCHROME P450 ENZYMES AND C-JUN N-TERMINAL KINASE ACTIVATION

Acetaminophen (APAP) hepatotoxicity is the leading cause of acute liver failure in the US. Although many aspects of the mechanism are known, recent publications suggest that gap junctions composed of connexin32 function as critical intercellular communication channels which transfer cytotoxic mediat...

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Detalhes bibliográficos
Main Authors: Du, Kuo, Williams, C. David, McGill, Mitchell R., Xie, Yuchao, Farhood, Anwar, Vinken, Mathieu, Jaeschke, Hartmut
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3858533/
https://ncbi.nlm.nih.gov/pubmed/24070586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2013.09.010
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