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PATHOPHYSIOLOGICAL SIGNIFICANCE OF C-JUN N-TERMINAL KINASE IN ACETAMINOPHEN HEPATOTOXICITY

BACKGROUND: Acetaminophen (APAP) overdose is the leading cause of acute liver failure in the US. Although substantial progress regarding the mechanisms of APAP hepatotoxicity has been made in the past several decades, therapeutic options are still limited and novel treatments are clearly needed. c-j...

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Detalhes bibliográficos
Publicado no:Expert Opin Drug Metab Toxicol
Main Authors: Du, Kuo, Xie, Yuchao, McGill, Mitchell R., Jaeschke, Hartmut
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4827771/
https://ncbi.nlm.nih.gov/pubmed/26190663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/17425255.2015.1071353
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