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PATHOPHYSIOLOGICAL SIGNIFICANCE OF C-JUN N-TERMINAL KINASE IN ACETAMINOPHEN HEPATOTOXICITY

BACKGROUND: Acetaminophen (APAP) overdose is the leading cause of acute liver failure in the US. Although substantial progress regarding the mechanisms of APAP hepatotoxicity has been made in the past several decades, therapeutic options are still limited and novel treatments are clearly needed. c-j...

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Publicat a:Expert Opin Drug Metab Toxicol
Autors principals: Du, Kuo, Xie, Yuchao, McGill, Mitchell R., Jaeschke, Hartmut
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4827771/
https://ncbi.nlm.nih.gov/pubmed/26190663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/17425255.2015.1071353
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