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RESVERATROL PREVENTS PROTEIN NITRATION AND RELEASE OF ENDONUCLEASES FROM MITOCHONDRIA DURING ACETAMINOPHEN HEPATOTOXICITY
Overdose of acetaminophen (APAP) is a common cause of acute liver injury and liver failure. The mechanism involves formation of a reactive metabolite, protein binding, oxidative stress and activation of c-Jun N-terminal kinase (JNK), mitochondrial dysfunction, and nuclear DNA fragmentation caused by...
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| Izdano u: | Food Chem Toxicol |
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| Glavni autori: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4450137/ https://ncbi.nlm.nih.gov/pubmed/25865938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fct.2015.04.014 |
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