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RESVERATROL PREVENTS PROTEIN NITRATION AND RELEASE OF ENDONUCLEASES FROM MITOCHONDRIA DURING ACETAMINOPHEN HEPATOTOXICITY

Overdose of acetaminophen (APAP) is a common cause of acute liver injury and liver failure. The mechanism involves formation of a reactive metabolite, protein binding, oxidative stress and activation of c-Jun N-terminal kinase (JNK), mitochondrial dysfunction, and nuclear DNA fragmentation caused by...

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Detalhes bibliográficos
Publicado no:Food Chem Toxicol
Main Authors: Du, Kuo, McGill, Mitchell R., Xie, Yuchao, Bajt, Mary Lynn, Jaeschke, Hartmut
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4450137/
https://ncbi.nlm.nih.gov/pubmed/25865938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fct.2015.04.014
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