LYSOSOMAL INSTABILITY AND CATHEPSIN B RELEASE DURING ACETAMINOPHEN HEPATOTOXICITY

Acetaminophen (APAP) overdose is currently the most frequent cause of drug-induced liver failure in the United States. Recently, it was shown that lysosomal iron translocates to mitochondria where it contributes to collapse of the mitochondrial membrane potential. Therefore, the purpose of this stud...

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Bibliografiset tiedot
Päätekijät: Woolbright, Benjamin L., Ramachandran, Anup, McGill, Mitchell R., Yan, Hui-min, Bajt, Mary Lynn, Sharpe, Matthew R., Lemasters, John J., Jaeschke, Hartmut
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2012
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501614/
https://ncbi.nlm.nih.gov/pubmed/22900545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-7843.2012.00931.x
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