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OXIDANT STRESS, MITOCHONDRIA AND CELL DEATH MECHANISMS IN DRUG-INDUCED LIVER INJURY: LESSONS LEARNED FROM ACETAMINOPHEN HEPATOTOXICITY

Hepatotoxicity is a serious problem during drug development and for the use of many established drugs. For example, acetaminophen overdose is currently the most frequent cause of acute liver failure in the United States and Great Britain. Evaluation of the mechanisms of drug-induced liver injury ind...

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書目詳細資料
發表在:Drug Metab Rev
Main Authors: Jaeschke, Hartmut, McGill, Mitchell R., Ramachandran, Anup
格式: Artigo
語言:Inglês
出版: 2012
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5319847/
https://ncbi.nlm.nih.gov/pubmed/22229890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/03602532.2011.602688
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