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Mechanistic Biomarkers in Acetaminophen-induced Hepatotoxicity and Acute Liver Failure: From Preclinical Models to Patients

INTRODUCTION: Drug hepatotoxicity is a major clinical issue. Acetaminophen (APAP) overdose is especially common. Serum biomarkers used to follow patient progress reflect either liver injury or function, but focus on biomarkers that can provide insight into the basic mechanisms of hepatotoxicity is i...

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Bibliografske podrobnosti
izdano v:Expert Opin Drug Metab Toxicol
Main Authors: McGill, Mitchell R., Jaeschke, Hartmut
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4414250/
https://ncbi.nlm.nih.gov/pubmed/24836926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/17425255.2014.920823
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