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Mechanistic Biomarkers in Acetaminophen-induced Hepatotoxicity and Acute Liver Failure: From Preclinical Models to Patients

INTRODUCTION: Drug hepatotoxicity is a major clinical issue. Acetaminophen (APAP) overdose is especially common. Serum biomarkers used to follow patient progress reflect either liver injury or function, but focus on biomarkers that can provide insight into the basic mechanisms of hepatotoxicity is i...

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Bibliographische Detailangaben
Veröffentlicht in:Expert Opin Drug Metab Toxicol
Hauptverfasser: McGill, Mitchell R., Jaeschke, Hartmut
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4414250/
https://ncbi.nlm.nih.gov/pubmed/24836926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/17425255.2014.920823
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