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Cytochrome P450-derived versus Mitochondrial Oxidant Stress in Acetaminophen Hepatotoxicity
In evaluating the mechanisms of acetaminophen hepatotoxicity in experimental systems, it is critical to keep in mind the relevance of the model system for humans. Important aspects of the human toxicity include formation of a reactive metabolite by the cytochrome P450 system and protein adduct forma...
Gardado en:
| Publicado en: | Toxicol Lett |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4536554/ https://ncbi.nlm.nih.gov/pubmed/25858113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2015.04.002 |
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