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Cytochrome P450-derived versus Mitochondrial Oxidant Stress in Acetaminophen Hepatotoxicity
In evaluating the mechanisms of acetaminophen hepatotoxicity in experimental systems, it is critical to keep in mind the relevance of the model system for humans. Important aspects of the human toxicity include formation of a reactive metabolite by the cytochrome P450 system and protein adduct forma...
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| Pubblicato in: | Toxicol Lett |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4536554/ https://ncbi.nlm.nih.gov/pubmed/25858113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2015.04.002 |
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