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Oxidant Stress and Lipid Peroxidation in Acetaminophen Hepatotoxicity

Acetaminophen (APAP) overdose is the most frequent cause of liver injury and acute liver failure in many western countries. The mechanism of APAP-induced hepatocyte necrosis has been investigated extensively. The formation of a reactive metabolite and its binding to cellular proteins was initially t...

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Detalhes bibliográficos
Publicado no:React Oxyg Species (Apex)
Main Authors: Jaeschke, Hartmut, Ramachandran, Anup
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5903282/
https://ncbi.nlm.nih.gov/pubmed/29682614
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