Editor’s Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction

Overdose of acetaminophen (APAP) causes severe liver injury and even acute liver failure in both mice and human. A recent study by Kim et al. (2015, Metformin ameliorates acetaminophen hepatotoxicity via Gadd45β-dependent regulation of JNK signaling in mice. J. Hepatol. 63, 75–82) showed that metfor...

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Detaylı Bibliyografya
Yayımlandı:Toxicol Sci
Asıl Yazarlar: Du, Kuo, Ramachandran, Anup, Weemhoff, James L., Chavan, Hemantkumar, Xie, Yuchao, Krishnamurthy, Partha, Jaeschke, Hartmut
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2016
Konular:
Mechanisms of Metformin Protection Against Acetaminophen Toxicity in Liver
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5139063/
https://ncbi.nlm.nih.gov/pubmed/27562556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw158
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