Editor’s Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction

Overdose of acetaminophen (APAP) causes severe liver injury and even acute liver failure in both mice and human. A recent study by Kim et al. (2015, Metformin ameliorates acetaminophen hepatotoxicity via Gadd45β-dependent regulation of JNK signaling in mice. J. Hepatol. 63, 75–82) showed that metfor...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Toxicol Sci
Main Authors: Du, Kuo, Ramachandran, Anup, Weemhoff, James L., Chavan, Hemantkumar, Xie, Yuchao, Krishnamurthy, Partha, Jaeschke, Hartmut
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2016
Teme:
Mechanisms of Metformin Protection Against Acetaminophen Toxicity in Liver
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5139063/
https://ncbi.nlm.nih.gov/pubmed/27562556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw158
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