Bedaquiline Metabolism: Enzymes and Novel Metabolites

Por Liu, Ke, Li, Feng, Lu, Jie, Liu, Shinlan, Dorko, Kenneth, Xie, Wen, Ma, Xiaochao
Publicado em 2014

Dynamic Arginine Methylation of Tumor Necrosis Factor (TNF) Receptor-associated Factor 6 Regulates Toll-like Receptor Signaling

Por Tikhanovich, Irina, Kuravi, Sudhakiranmayi, Artigues, Antonio, Villar, Maria T., Dorko, Kenneth, Nawabi, Atta, Roberts, Benjamin, Weinman, Steven A.
Publicado no J Biol Chem (2015)

Adenoviral-mediated correction of methylmalonyl-CoA mutase deficiency in murine fibroblasts and human hepatocytes

Por Chandler, Randy J, Tsai, Matthew S, Dorko, Kenneth, Sloan, Jennifer, Korson, Mark, Freeman, Richard, Strom, Stephen, Venditti, Charles P
Publicado em 2007

Mechanisms of Acetaminophen-induced Cell Death in Primary Human Hepatocytes

Por Xie, Yuchao, McGill, Mitchell R., Dorko, Kenneth, Kumer, Sean C., Schmitt, Timothy M., Forster, Jameson, Jaeschke, Hartmut
Publicado em 2014

The History and Use of Human Hepatocytes for the Study and Treatment of Liver Metabolic Diseases

Por Hansel, Marc C., Gramignoli, Roberto, Skvorak, Kristen J., Dorko, Kenneth, Marongiu, Fabio, Blake, William, Davila, Julio, Strom, Stephen C.
Publicado no Curr Protoc Toxicol (2014)

Maintenance of Human Hepatocyte Function In Vitro by Liver-Derived Extracellular Matrix Gels

Por Sellaro, Tiffany L., Ranade, Aarati, Faulk, Denver M., McCabe, George P., Dorko, Kenneth, Badylak, Stephen F., Strom, Stephen C.
Publicado em 2010

Metabolism of 17α-Hydroxyprogesterone Caproate, an Agent for Preventing Preterm Birth, by Fetal Hepatocytes

Por Sharma, Shringi, Ellis, Ewa C. S., Dorko, Kenneth, Zhang, Shimin, Mattison, Donald R., Caritis, Steve N., Venkataramanan, Raman, Strom, Stephen C.
Publicado em 2010

Placental Stem Cell Correction of Murine Intermediate Maple Syrup Urine Disease

Por Skvorak, Kristen J., Dorko, Kenneth, Marongiu, Fabio, Tahan, Veysel, Hansel, Marc C., Gramignoli, Roberto, Gibson, K. Michael, Strom, Stephen C.
Publicado em 2013

Functional Coupling of ATP-binding Cassette Transporter Abcb6 to Cytochrome P450 Expression and Activity in Liver

Por Chavan, Hemantkumar, Li, Feng, Tessman, Robert, Mickey, Kristen, Dorko, Kenneth, Schmitt, Timothy, Kumer, Sean, Gunewardena, Sumedha, Gaikwad, Nilesh, Krishnamurthy, Partha
Publicado no J Biol Chem (2015)

The second extracellular loop dictates Occludin-mediated HCV entry

Por Liu, Shufeng, Kuo, Wayne, Yang, Wei, Liu, Weiqun, Gibson, Gregory A., Dorko, Kenneth, Watkins, Simon C., Strom, Stephen C., Wang, Tianyi
Publicado em 2010

Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes

Por Xie, Yuchao, McGill, Mitchell R., Du, Kuo, Dorko, Kenneth, Kumer, Sean C., Schmitt, Timothy M., Ding, Wen-Xing, Jaeschke, Hartmut
Publicado no Toxicol Appl Pharmacol (2015)

Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen Hepatotoxicity

Por Xie, Yuchao, Woolbright, Benjamin L., Kos, Milan, McGill, Mitchell R., Dorko, Kenneth, Kumer, Sean C., Schmitt, Timothy M., Jaeschke, Hartmut
Publicado no J Clin Transl Res (2015)

The Use of Induced Pluripotent Stem Cells for the Study and Treatment of Liver Diseases

Por Hansel, Marc C., Davila, Julio C., Vosough, Massoud, Gramignoli, Roberto, Skvorak, Kristen J., Dorko, Kenneth, Marongiu, Fabio, Blake, William, Strom, Stephen C.
Publicado no Curr Protoc Toxicol (2016)

Increased hepatic receptor interacting protein kinase 3 expression due to impaired proteasomal functions contributes to alcohol-induced steatosis and liver injury

Por Wang, Shaogui, Ni, Hong-Min, Dorko, Kenneth, Kumer, Sean C., Schmitt, Timothy M., Nawabi, Atta, Komatsu, Masaaki, Huang, Heqing, Ding, Wen-Xing
Publicado no Oncotarget (2016)

Hepatocyte Transplantation Improves Phenotype and Extends Survival in a Murine Model of Intermediate Maple Syrup Urine Disease

Por Skvorak, Kristen J, Paul, Harbhajan S, Dorko, Kenneth, Marongiu, Fabio, Ellis, Ewa, Chace, Donald, Ferguson, Carolyn, Gibson, K Michael, Homanics, Gregg E, Strom, Stephen C
Publicado em 2009

Role of Chromatin Structural Changes in Regulating Human CYP3A Ontogeny

Por Giebel, Nicholas L., Shadley, Jeffrey D., McCarver, D. Gail, Dorko, Kenneth, Gramignoli, Roberto, Strom, Stephen C., Yan, Ke, Simpson, Pippa M., Hines, Ronald N.
Publicado no Drug Metab Dispos (2016)

Hepatobiliary Disposition of 17-OHPC and Taurocholate in Fetal Human Hepatocytes: A Comparison with Adult Human Hepatocytes

Por Sharma, Shringi, Ellis, Ewa C. S., Gramignoli, Roberto, Dorko, Kenneth, Tahan, Veysel, Hansel, Marc, Mattison, Donald R., Caritis, Steve N., Hines, Ronald N., Venkataramanan, Raman, Strom, Stephen C.
Publicado em 2013

The proteome of methylmalonic acidemia (MMA): elucidation of altered pathways in patient livers

Por Caterino, Marianna, Chandler, Randy J., Sloan, Jennifer L., Dorko, Kenneth, Cusmano-Ozog, Kristina, Ingenito, Laura, Strom, Stephen C., Imperlini, Esther, Scolamiero, Emanuela, Venditti, Charles P., Ruoppolo, Margherita
Publicado no Mol Biosyst (2016)

Increased Reprogramming of Human Fetal Hepatocytes Compared With Adult Hepatocytes in Feeder-Free Conditions

Por Hansel, Marc C., Gramignoli, Roberto, Blake, William, Davila, Julio, Skvorak, Kristen, Dorko, Kenneth, Tahan, Veysel, Lee, Brian R., Tafaleng, Edgar, Guzman-Lepe, Jorge, Soto-Gutierrez, Alejandro, Fox, Ira J., Strom, Stephen C.
Publicado em 2013

Bile Acid-Induced Necrosis in Primary Human Hepatocytes and in Patients with Obstructive Cholestasis

Por Woolbright, Benjamin L., Dorko, Kenneth, Antoine, Daniel J., Clarke, Joanna I., Gholami, Parviz, Li, Feng, Kumer, Sean C., Schmitt, Timothy M., Forster, Jameson, Fan, Fang, Jenkins, Rosalind E., Park, B. Kevin, Hagenbuch, Bruno, Olyaee, Mojtaba, Jaeschke, Hartmut
Publicado no Toxicol Appl Pharmacol (2015)