Bile Acid-Induced Necrosis in Primary Human Hepatocytes and in Patients with Obstructive Cholestasis

Accumulation of bile acids is a major mediator of cholestatic liver injury. Recent studies indicate bile acid composition between humans and rodents is dramatically different, as humans have a higher percent of glycine conjugated bile acids and increased chenodeoxycholate content, which increases th...

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Detalhes bibliográficos
Publicado no:Toxicol Appl Pharmacol
Main Authors: Woolbright, Benjamin L., Dorko, Kenneth, Antoine, Daniel J., Clarke, Joanna I., Gholami, Parviz, Li, Feng, Kumer, Sean C., Schmitt, Timothy M., Forster, Jameson, Fan, Fang, Jenkins, Rosalind E., Park, B. Kevin, Hagenbuch, Bruno, Olyaee, Mojtaba, Jaeschke, Hartmut
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4361327/
https://ncbi.nlm.nih.gov/pubmed/25636263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2015.01.015
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