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Microcystin-LR Induced Liver Injury in Mice and in Primary Human Hepatocytes is Caused by Oncotic Necrosis
Microcystins are a group of toxins produced by freshwater cyanobacteria. Uptake of microcystin-leucine arginine (MC-LR) by organic anion transporting polypeptide 1B2 in hepatocytes results in inhibition of protein phosphatase 1A and 2A, and subsequent cell death. Studies performed in primary rat hep...
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| Publicado no: | Toxicon |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5193107/ https://ncbi.nlm.nih.gov/pubmed/27889601 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxicon.2016.11.254 |
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