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Oxidant stress-induced liver injury in vivo: role of apoptosis, oncotic necrosis, and c-Jun NH(2)-terminal kinase activation
Oxidant stress is critically involved in various liver diseases. Superoxide formation causes c-Jun NH(2)-terminal kinase (JNK)- and caspase-dependent apoptosis in cultured hepatocytes. To verify these findings in vivo, male Fisher rats were treated with diquat and menadione. The oxidant stress induc...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2660174/ https://ncbi.nlm.nih.gov/pubmed/19136381 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.90435.2008 |
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