Purinergic Receptor Antagonist A438079 Protects Against Acetaminophen-Induced Liver Injury by Inhibiting P450 Isoenzymes, Not by Inflammasome Activation

Acetaminophen (APAP) overdose is the most frequent cause of acute liver failure in the western world. Controversy exists regarding the hypothesis that the hepatocyte injury is amplified by a sterile inflammatory response, rather than being the result of intracellular mechanisms alone. A recent study...

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Bibliografiska uppgifter
Huvudupphovsmän: Xie, Yuchao, Williams, C. David, McGill, Mitchell R., Lebofsky, Margitta, Ramachandran, Anup, Jaeschke, Hartmut
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2013
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537131/
https://ncbi.nlm.nih.gov/pubmed/22986947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfs283
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