PROTECTION AGAINST ACETAMINOPHEN-INDUCED LIVER INJURY BY ALLOPURINOL IS DEPENDENT ON ALDEHYDE OXIDASE-MEDIATED LIVER PRECONDITIONING

Acetaminophen (APAP) overdose causes severe and occasionally fatal liver injury. Numerous drugs that attenuate APAP toxicity have been described. However these compounds frequently protect by cytochrome P450 inhibition, thereby preventing the initiating step of toxicity. We have previously shown tha...

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Bibliografische gegevens
Hoofdauteurs: Williams, C. David, McGill, Mitchell R., Lebofsky, Margitta, Bajt, Mary Lynn, Jaeschke, Hartmut
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3939778/
https://ncbi.nlm.nih.gov/pubmed/24345528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2013.12.003
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