PROTECTION AGAINST ACETAMINOPHEN-INDUCED LIVER INJURY BY ALLOPURINOL IS DEPENDENT ON ALDEHYDE OXIDASE-MEDIATED LIVER PRECONDITIONING

Acetaminophen (APAP) overdose causes severe and occasionally fatal liver injury. Numerous drugs that attenuate APAP toxicity have been described. However these compounds frequently protect by cytochrome P450 inhibition, thereby preventing the initiating step of toxicity. We have previously shown tha...

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Detalhes bibliográficos
Main Authors: Williams, C. David, McGill, Mitchell R., Lebofsky, Margitta, Bajt, Mary Lynn, Jaeschke, Hartmut
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3939778/
https://ncbi.nlm.nih.gov/pubmed/24345528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2013.12.003
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