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PROTECTION AGAINST ACETAMINOPHEN-INDUCED LIVER INJURY BY ALLOPURINOL IS DEPENDENT ON ALDEHYDE OXIDASE-MEDIATED LIVER PRECONDITIONING

Acetaminophen (APAP) overdose causes severe and occasionally fatal liver injury. Numerous drugs that attenuate APAP toxicity have been described. However these compounds frequently protect by cytochrome P450 inhibition, thereby preventing the initiating step of toxicity. We have previously shown tha...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Williams, C. David, McGill, Mitchell R., Lebofsky, Margitta, Bajt, Mary Lynn, Jaeschke, Hartmut
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3939778/
https://ncbi.nlm.nih.gov/pubmed/24345528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2013.12.003
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