Liver-Specific Loss of Atg5 Causes Persistent Activation of Nrf2 and Protects Against Acetaminophen-Induced Liver Injury

Autophagy is an evolutionarily conserved biological process that degrades intracellular proteins and organelles including damaged mitochondria through the formation of autophagosome. We have previously demonstrated that pharmacological induction of autophagy by rapamycin protects against acetaminoph...

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Hlavní autoři: Ni, Hong-Min, Boggess, Nikki, McGill, Mitchell R., Lebofsky, Margitta, Borude, Prachi, Apte, Udayan, Jaeschke, Hartmut, Ding, Wen-Xing
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
Molecular Toxicology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3355320/
https://ncbi.nlm.nih.gov/pubmed/22491424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfs133
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