Liver-Specific Loss of Atg5 Causes Persistent Activation of Nrf2 and Protects Against Acetaminophen-Induced Liver Injury

Autophagy is an evolutionarily conserved biological process that degrades intracellular proteins and organelles including damaged mitochondria through the formation of autophagosome. We have previously demonstrated that pharmacological induction of autophagy by rapamycin protects against acetaminoph...

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Detalhes bibliográficos
Main Authors: Ni, Hong-Min, Boggess, Nikki, McGill, Mitchell R., Lebofsky, Margitta, Borude, Prachi, Apte, Udayan, Jaeschke, Hartmut, Ding, Wen-Xing
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Molecular Toxicology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3355320/
https://ncbi.nlm.nih.gov/pubmed/22491424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfs133
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