Liver-Specific Loss of Atg5 Causes Persistent Activation of Nrf2 and Protects Against Acetaminophen-Induced Liver Injury

Autophagy is an evolutionarily conserved biological process that degrades intracellular proteins and organelles including damaged mitochondria through the formation of autophagosome. We have previously demonstrated that pharmacological induction of autophagy by rapamycin protects against acetaminoph...

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Main Authors: Ni, Hong-Min, Boggess, Nikki, McGill, Mitchell R., Lebofsky, Margitta, Borude, Prachi, Apte, Udayan, Jaeschke, Hartmut, Ding, Wen-Xing
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2012
Ábhair:
Molecular Toxicology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3355320/
https://ncbi.nlm.nih.gov/pubmed/22491424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfs133
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