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Pleiotropic Role of p53 in Injury and Liver Regeneration after Acetaminophen Overdose
p53 is the major cellular gatekeeper involved in proliferation, cell death, migration, and homeostasis. The role of p53 in pathogenesis of drug-induced liver injury is unknown. We investigated the role of p53 in liver injury and regeneration after acetaminophen (APAP) overdose, the most common cause...
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| Veröffentlicht in: | Am J Pathol |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Investigative Pathology
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5971235/ https://ncbi.nlm.nih.gov/pubmed/29654721 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2018.03.006 |
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