Pleiotropic Role of p53 in Injury and Liver Regeneration after Acetaminophen Overdose

p53 is the major cellular gatekeeper involved in proliferation, cell death, migration, and homeostasis. The role of p53 in pathogenesis of drug-induced liver injury is unknown. We investigated the role of p53 in liver injury and regeneration after acetaminophen (APAP) overdose, the most common cause...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Am J Pathol
Prif Awduron: Borude, Prachi, Bhushan, Bharat, Gunewardena, Sumedha, Akakpo, Jephte, Jaeschke, Hartmut, Apte, Udayan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Investigative Pathology 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971235/
https://ncbi.nlm.nih.gov/pubmed/29654721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2018.03.006
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