Liver-Specific Loss of Atg5 Causes Persistent Activation of Nrf2 and Protects Against Acetaminophen-Induced Liver Injury

Autophagy is an evolutionarily conserved biological process that degrades intracellular proteins and organelles including damaged mitochondria through the formation of autophagosome. We have previously demonstrated that pharmacological induction of autophagy by rapamycin protects against acetaminoph...

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Détails bibliographiques
Auteurs principaux: Ni, Hong-Min, Boggess, Nikki, McGill, Mitchell R., Lebofsky, Margitta, Borude, Prachi, Apte, Udayan, Jaeschke, Hartmut, Ding, Wen-Xing
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2012
Sujets:
Molecular Toxicology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3355320/
https://ncbi.nlm.nih.gov/pubmed/22491424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfs133
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