Plasma and Liver Acetaminophen-Protein Adduct Levels in Mice after Acetaminophen Treatment: Dose-Response, Mechanisms, and Clinical Implications

At therapeutic doses, acetaminophen (APAP) is a safe and effective analgesic. However, overdose of APAP is the principal cause of acute liver failure in the West. Binding of the reactive metabolite of APAP (NAPQI) to proteins is thought to be the initiating event in the mechanism of hepatotoxicity....

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: McGill, Mitchell R., Lebofsky, Margitta, Norris, Hye-Ryun K., Slawson, Matthew H., Bajt, Mary Lynn, Xie, Yuchao, Williams, C. David, Wilkins, Diana G., Rollins, Douglas E., Jaeschke, Hartmut
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3654056/
https://ncbi.nlm.nih.gov/pubmed/23571099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2013.03.026
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk