Plasma and Liver Acetaminophen-Protein Adduct Levels in Mice after Acetaminophen Treatment: Dose-Response, Mechanisms, and Clinical Implications

At therapeutic doses, acetaminophen (APAP) is a safe and effective analgesic. However, overdose of APAP is the principal cause of acute liver failure in the West. Binding of the reactive metabolite of APAP (NAPQI) to proteins is thought to be the initiating event in the mechanism of hepatotoxicity....

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Main Authors: McGill, Mitchell R., Lebofsky, Margitta, Norris, Hye-Ryun K., Slawson, Matthew H., Bajt, Mary Lynn, Xie, Yuchao, Williams, C. David, Wilkins, Diana G., Rollins, Douglas E., Jaeschke, Hartmut
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3654056/
https://ncbi.nlm.nih.gov/pubmed/23571099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2013.03.026
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