Plasma and Liver Acetaminophen-Protein Adduct Levels in Mice after Acetaminophen Treatment: Dose-Response, Mechanisms, and Clinical Implications

At therapeutic doses, acetaminophen (APAP) is a safe and effective analgesic. However, overdose of APAP is the principal cause of acute liver failure in the West. Binding of the reactive metabolite of APAP (NAPQI) to proteins is thought to be the initiating event in the mechanism of hepatotoxicity....

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: McGill, Mitchell R., Lebofsky, Margitta, Norris, Hye-Ryun K., Slawson, Matthew H., Bajt, Mary Lynn, Xie, Yuchao, Williams, C. David, Wilkins, Diana G., Rollins, Douglas E., Jaeschke, Hartmut
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3654056/
https://ncbi.nlm.nih.gov/pubmed/23571099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2013.03.026
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak