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Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury

Acetaminophen (APAP) hepatotoxicity is the main cause of acute liver failure in humans. Although mitochondrial oxidant stress and induction of the mitochondrial permeability transition (MPT) have been implicated in APAP-induced hepatotoxicity, the link between these events is unclear. To investigate...

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Autors principals: RAMACHANDRAN, ANUP, LEBOFSKY, MARGITTA, BAINES, CHRISTOPHER P., LEMASTERS, JOHN J., JAESCHKE, HARTMUT
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3899524/
https://ncbi.nlm.nih.gov/pubmed/20942566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10715762.2010.520319
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