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THE IMPACT OF PARTIAL MANGANESE SUPEROXIDE DISMUTASE (SOD2)-DEFICIENCY ON MITOCHONDRIAL OXIDANT STRESS, DNA FRAGMENTATION AND LIVER INJURY DURING ACETAMINOPHEN HEPATOTOXICITY
Acetaminophen (APAP) hepatotoxicity is the most frequent cause of acute liver failure in many countries. The mechanism of cell death is initiated by formation of a reactive metabolite that binds to mitochondrial proteins and promotes mitochondrial dysfunction and oxidant stress. Manganese superoxide...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3050115/ https://ncbi.nlm.nih.gov/pubmed/21241727 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2011.01.004 |
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